1:"$Sreact.fragment" 2:I[79520,["/_next/static/chunks/29xvpf6gzvbvu.js","/_next/static/chunks/1-8s9_t85wwr4.js"],""] 3:I[59919,["/_next/static/chunks/29xvpf6gzvbvu.js","/_next/static/chunks/1-8s9_t85wwr4.js"],"ThemeProvider"] 4:I[2971,["/_next/static/chunks/29xvpf6gzvbvu.js","/_next/static/chunks/1-8s9_t85wwr4.js"],"Header"] 5:I[39756,["/_next/static/chunks/29xvpf6gzvbvu.js","/_next/static/chunks/1-8s9_t85wwr4.js"],"default"] 6:I[37457,["/_next/static/chunks/29xvpf6gzvbvu.js","/_next/static/chunks/1-8s9_t85wwr4.js"],"default"] 7:I[22016,["/_next/static/chunks/29xvpf6gzvbvu.js","/_next/static/chunks/1-8s9_t85wwr4.js"],""] 8:I[5014,["/_next/static/chunks/29xvpf6gzvbvu.js","/_next/static/chunks/1-8s9_t85wwr4.js","/_next/static/chunks/1d1y7uymgsv0g.js"],"default"] f:I[68027,["/_next/static/chunks/29xvpf6gzvbvu.js","/_next/static/chunks/1-8s9_t85wwr4.js"],"default",1] :HL["/_next/static/chunks/34uzstzdlvob4.css","style"] :HL["/_next/static/media/797e433ab948586e-s.p.0r6juujl39pe6.woff2","font",{"crossOrigin":"","type":"font/woff2"}] :HL["/_next/static/media/caa3a2e1cccd8315-s.p.0wgildi0cnwt9.woff2","font",{"crossOrigin":"","type":"font/woff2"}] 0:{"P":null,"c":["","therapeutics"],"q":"","i":false,"f":[[["",{"children":["therapeutics",{"children":["__PAGE__",{}]}]},"$undefined","$undefined",16],[["$","$1","c",{"children":[[["$","link","0",{"rel":"stylesheet","href":"/_next/static/chunks/34uzstzdlvob4.css","precedence":"next","crossOrigin":"$undefined","nonce":"$undefined"}],["$","script","script-0",{"src":"/_next/static/chunks/29xvpf6gzvbvu.js","async":true,"nonce":"$undefined"}],["$","script","script-1",{"src":"/_next/static/chunks/1-8s9_t85wwr4.js","async":true,"nonce":"$undefined"}]],["$","html",null,{"lang":"en","className":"geist_a71539c9-module__T19VSG__variable geist_mono_8d43a2aa-module__8Li5zG__variable h-full antialiased","suppressHydrationWarning":true,"children":["$","body",null,{"className":"flex min-h-full flex-col bg-background text-foreground","children":[["$","$L2",null,{"src":"https://www.googletagmanager.com/gtag/js?id=G-148SD45Q9N","strategy":"afterInteractive"}],["$","$L2",null,{"id":"google-analytics","strategy":"afterInteractive","children":"window.dataLayer = window.dataLayer || [];\n function gtag(){dataLayer.push(arguments);}\n gtag('js', new Date());\n gtag('config', 'G-148SD45Q9N');"}],["$","$L3",null,{"children":[["$","$L4",null,{}],["$","main",null,{"className":"mx-auto w-full max-w-6xl flex-1 px-4 py-8 sm:px-6 lg:px-8","children":["$","$L5",null,{"parallelRouterKey":"children","error":"$undefined","errorStyles":"$undefined","errorScripts":"$undefined","template":["$","$L6",null,{}],"templateStyles":"$undefined","templateScripts":"$undefined","notFound":[[["$","title",null,{"children":"404: This page could not be found."}],["$","div",null,{"style":{"fontFamily":"system-ui,\"Segoe UI\",Roboto,Helvetica,Arial,sans-serif,\"Apple Color Emoji\",\"Segoe UI Emoji\"","height":"100vh","textAlign":"center","display":"flex","flexDirection":"column","alignItems":"center","justifyContent":"center"},"children":["$","div",null,{"children":[["$","style",null,{"dangerouslySetInnerHTML":{"__html":"body{color:#000;background:#fff;margin:0}.next-error-h1{border-right:1px solid rgba(0,0,0,.3)}@media (prefers-color-scheme:dark){body{color:#fff;background:#000}.next-error-h1{border-right:1px solid rgba(255,255,255,.3)}}"}}],["$","h1",null,{"className":"next-error-h1","style":{"display":"inline-block","margin":"0 20px 0 0","padding":"0 23px 0 0","fontSize":24,"fontWeight":500,"verticalAlign":"top","lineHeight":"49px"},"children":404}],["$","div",null,{"style":{"display":"inline-block"},"children":["$","h2",null,{"style":{"fontSize":14,"fontWeight":400,"lineHeight":"49px","margin":0},"children":"This page could not be found."}]}]]}]}]],[]],"forbidden":"$undefined","unauthorized":"$undefined"}]}],["$","footer",null,{"className":"mt-auto","style":{"backgroundColor":"#0e1444","color":"rgba(255,255,255,0.45)"},"children":["$","div",null,{"className":"mx-auto max-w-6xl px-4 pt-8 sm:px-6 lg:px-8","children":[["$","div",null,{"className":"grid gap-8 sm:grid-cols-3","children":[["$","div",null,{"children":[["$","p",null,{"className":"text-sm font-semibold text-white/80","children":"spikeprotein.online"}],["$","p",null,{"className":"mt-2 text-xs leading-relaxed text-white/45","children":"An evidence-based scientific resource on SARS-CoV-2 spike protein persistence and related research — part of the OpenSourceMed network."}]]}],["$","div",null,{"children":[["$","p",null,{"className":"text-sm font-semibold text-white/80","children":"Resources"}],["$","ul",null,{"className":"mt-2 space-y-1.5 text-xs text-white/45","children":[["$","li",null,{"children":["$","$L7",null,{"href":"/literature","className":"transition-colors hover:text-[#ff9800]","children":"Literature database"}]}],["$","li",null,{"children":["$","$L7",null,{"href":"/levels","className":"transition-colors hover:text-[#ff9800]","children":"Measured levels & durations"}]}],["$","li",null,{"children":["$","$L7",null,{"href":"/about","className":"transition-colors hover:text-[#ff9800]","children":"Sources & methodology"}]}]]}]]}],["$","div",null,{"children":[["$","p",null,{"className":"text-sm font-semibold text-white/80","children":"Sponsored by"}],["$","a",null,{"href":"https://opensourcemed.info","target":"_blank","rel":"noopener noreferrer","className":"mt-2 inline-flex items-center gap-1 text-sm font-medium text-[#ff9800] transition-colors hover:text-[#e64a19]","children":["OpenSourceMed.info",["$","$L8",null,{"ref":"$undefined","iconNode":[["path",{"d":"M15 3h6v6","key":"1q9fwt"}],["path",{"d":"M10 14 21 3","key":"gplh6r"}],["path",{"d":"M18 13v6a2 2 0 0 1-2 2H5a2 2 0 0 1-2-2V8a2 2 0 0 1 2-2h6","key":"a6xqqp"}]],"className":"lucide-external-link h-3 w-3","aria-hidden":"true"}]]}],"$L9"]}]]}],"$La"]}]}]]}]]}]}]]}],{"children":["$Lb",{"children":["$Lc",{},null,false,null]},null,false,"$@d"]},null,false,null],"$Le",false]],"m":"$undefined","G":["$f",["$L10"]],"S":true,"h":null,"s":"$undefined","l":"$undefined","p":"$undefined","d":"$undefined","b":"IMMGnmSvTMQHjLaCtjE3h"} 11:I[92604,["/_next/static/chunks/29xvpf6gzvbvu.js","/_next/static/chunks/1-8s9_t85wwr4.js","/_next/static/chunks/1d1y7uymgsv0g.js"],"SpikeTherapeuticsTable"] 1a:I[97367,["/_next/static/chunks/29xvpf6gzvbvu.js","/_next/static/chunks/1-8s9_t85wwr4.js"],"ViewportBoundary"] 1c:I[97367,["/_next/static/chunks/29xvpf6gzvbvu.js","/_next/static/chunks/1-8s9_t85wwr4.js"],"MetadataBoundary"] 1d:"$Sreact.suspense" 9:["$","p",null,{"className":"mt-2 text-xs leading-relaxed text-white/40","children":"Open-source medical research and education. Supporting evidence-based understanding of complex health topics."}] a:["$","div",null,{"className":"mt-8 flex flex-wrap items-center justify-between gap-4 border-t py-6 text-xs text-white/35","style":{"borderColor":"rgba(255,255,255,0.08)"},"children":[["$","span",null,{"children":["Last updated: ","July 6, 2026","· Not medical advice · Data is evolving"]}],["$","span",null,{"children":["Proudly part of the"," ",["$","a",null,{"href":"https://opensourcemed.info","target":"_blank","rel":"noopener noreferrer","className":"text-white/55 underline underline-offset-2 transition-colors hover:text-[#ff9800]","children":"OpenSourceMed.info"}]," ","network"]}]]}] b:["$","$1","c",{"children":[null,["$","$L5",null,{"parallelRouterKey":"children","error":"$undefined","errorStyles":"$undefined","errorScripts":"$undefined","template":["$","$L6",null,{}],"templateStyles":"$undefined","templateScripts":"$undefined","notFound":"$undefined","forbidden":"$undefined","unauthorized":"$undefined"}]]}] c:["$","$1","c",{"children":[["$","div",null,{"children":[["$","script",null,{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"MedicalWebPage\",\"name\":\"Spike Protein Therapeutics\",\"dateModified\":\"2026-07-06\"}"}}],["$","header",null,{"className":"mb-8","children":[["$","h1",null,{"className":"text-3xl font-bold tracking-tight text-foreground","children":"Therapeutics — Block, Degrade & Clear Spike"}],["$","p",null,{"className":"mt-3 max-w-3xl text-lg leading-relaxed text-muted-foreground","children":"Catalog of COVID-19, Long COVID, and PASC interventions proposed to neutralize, enzymatically degrade, or physically remove spike protein — with explicit clinical support assessment (RCT, authorized, pilot, or preclinical only)."}]]}],["$","aside",null,{"role":"note","aria-label":"Medical disclaimer","className":"rounded-lg border border-amber-300/60 bg-amber-50 px-4 py-3 text-sm text-amber-950 dark:border-amber-700/50 dark:bg-amber-950/40 dark:text-amber-100","children":["$","div",null,{"className":"flex gap-3","children":[["$","$L8",null,{"ref":"$undefined","iconNode":[["path",{"d":"m21.73 18-8-14a2 2 0 0 0-3.48 0l-8 14A2 2 0 0 0 4 21h16a2 2 0 0 0 1.73-3","key":"wmoenq"}],["path",{"d":"M12 9v4","key":"juzpu7"}],["path",{"d":"M12 17h.01","key":"p32p05"}]],"className":"lucide-triangle-alert mt-0.5 h-4 w-4 shrink-0 text-amber-600 dark:text-amber-400","aria-hidden":"true"}],["$","p",null,{"children":[["$","strong",null,{"children":"Disclaimer:"}]," This is not medical advice. Consult a healthcare professional. Data is evolving and subject to scientific revision."]}]]}]}],["$","div",null,{"className":"mt-8","children":["$","$L11",null,{}]}],["$","section",null,{"className":"mt-8 rounded-xl border border-border bg-card p-6","children":[["$","h2",null,{"className":"text-lg font-semibold text-foreground","children":"Clinical support legend"}],["$","ul",null,{"className":"mt-3 space-y-2 text-sm text-muted-foreground","children":[["$","li",null,{"children":[["$","strong",null,{"children":"FDA-approved/authorized"}]," — Regulatory approval for acute COVID-19 or prophylaxis; not necessarily long COVID or vaccine-spike clearance."]}],["$","li",null,{"children":[["$","strong",null,{"children":"RCT positive/negative"}]," — Randomized trial outcomes for claimed indication."]}],["$","li",null,{"children":[["$","strong",null,{"children":"Case series / pilot"}]," — Small human studies (e.g., Achleitner apheresis long-COVID cohort)."]}],["$","li",null,{"children":[["$","strong",null,{"children":"In vitro only"}]," — No robust human efficacy (e.g., nattokinase 2.5–25 µg/mL cell-free degradation)."]}],["$","li",null,{"children":[["$","strong",null,{"children":"Theoretical"}]," — Review or pharmacogenomic rationale without clinical validation."]}]]}]]}],["$","section",null,{"className":"mt-6 rounded-xl border border-amber-200 bg-amber-50 p-6 dark:border-amber-900 dark:bg-amber-950/30","children":[["$","h2",null,{"className":"text-lg font-semibold text-amber-900 dark:text-amber-100","children":"Clinical caution"}],["$","p",null,{"className":"mt-2 text-sm text-amber-800 dark:text-amber-200","children":"No intervention is established standard of care for vaccine-derived spike clearance. Halma et al. caution against nattokinase and bromelain in pregnancy/breastfeeding due to bleeding risk."}],["$","div",null,{"className":"mt-4","children":["$","ul",null,{"className":"mt-2 space-y-1","children":[["$","li","halma2025",{"className":"text-sm text-muted-foreground","children":["$","a",null,{"href":"https://onlinelibrary.wiley.com/doi/full/10.1155/av/7990876","target":"_blank","rel":"noopener noreferrer","className":"text-[#e64a19] hover:text-[#ff9800] hover:underline","children":["Halma MTJ, et al."," ","The Possible Mechanistic Basis of Individual Susceptibility to Spike Protein Injury",". ",["$","em",null,{"children":"Advances in Virology"}]," (",2025,")",["."," ",["$","span",null,{"className":"font-mono text-xs","children":["doi:","10.1155/av/7990876"]}]]]}]}],"$L12","$L13","$L14","$L15","$L16"]}]}]]}]]}],["$L17"],"$L18"]}] 19:[] d:"$W19" e:["$","$1","h",{"children":[null,["$","$L1a",null,{"children":"$L1b"}],["$","div",null,{"hidden":true,"children":["$","$L1c",null,{"children":["$","$1d",null,{"name":"Next.Metadata","children":"$L1e"}]}]}],["$","meta",null,{"name":"next-size-adjust","content":""}]]}] 10:["$","link","0",{"rel":"stylesheet","href":"/_next/static/chunks/34uzstzdlvob4.css","precedence":"next","crossOrigin":"$undefined","nonce":"$undefined"}] 1f:I[97367,["/_next/static/chunks/29xvpf6gzvbvu.js","/_next/static/chunks/1-8s9_t85wwr4.js"],"OutletBoundary"] 12:["$","li","halmaAutophagy2024",{"className":"text-sm text-muted-foreground","children":["$","a",null,{"href":"https://doi.org/10.1016/j.endmts.2024.100163","target":"_blank","rel":"noopener noreferrer","className":"text-[#e64a19] hover:text-[#ff9800] hover:underline","children":["Halma MTJ, Marik PE, Saleeby YM"," ","Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology",". ",["$","em",null,{"children":"Endocrine and Metabolic Science"}]," (",2024,")",["."," ",["$","span",null,{"className":"font-mono text-xs","children":["doi:","10.1016/j.endmts.2024.100163"]}]]]}]}] 13:["$","li","tanikawa2022",{"className":"text-sm text-muted-foreground","children":["$","a",null,{"href":"https://www.mdpi.com/1420-3049/27/23/8405","target":"_blank","rel":"noopener noreferrer","className":"text-[#e64a19] hover:text-[#ff9800] hover:underline","children":["Tanikawa T, et al."," ","Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2",". ",["$","em",null,{"children":"Molecules"}]," (",2022,")",["."," ",["$","span",null,{"className":"font-mono text-xs","children":["doi:","10.3390/molecules27238405"]}]]]}]}] 14:["$","li","achleitner2023",{"className":"text-sm text-muted-foreground","children":["$","a",null,{"href":"https://pubmed.ncbi.nlm.nih.gov/37291234/","target":"_blank","rel":"noopener noreferrer","className":"text-[#e64a19] hover:text-[#ff9800] hover:underline","children":["Achleitner M, et al."," ","Clinical improvement of long-COVID is associated with reduction in autoantibodies, lipids, and inflammation following therapeutic apheresis",". ",["$","em",null,{"children":"Molecular Psychiatry"}]," (",2023,")",["."," ",["$","span",null,{"className":"font-mono text-xs","children":["doi:","10.1038/s41380-023-02084-1"]}]]]}]}] 15:["$","li","spearTrial",{"className":"text-sm text-muted-foreground","children":["$","a",null,{"href":"https://clinicaltrials.gov/","target":"_blank","rel":"noopener noreferrer","className":"text-[#e64a19] hover:text-[#ff9800] hover:underline","children":["ClinicalTrials.gov"," ","SPEAR Trial — spike protein apheresis research",". ",["$","em",null,{"children":"Clinical trial registry"}]," (",2024,")","$undefined"]}]}] 16:["$","li","recoverTrial",{"className":"text-sm text-muted-foreground","children":["$","a",null,{"href":"https://recovercovid.org/","target":"_blank","rel":"noopener noreferrer","className":"text-[#e64a19] hover:text-[#ff9800] hover:underline","children":["NIH RECOVER Initiative"," ","RECOVER — Researching COVID to Enhance Recovery",". ",["$","em",null,{"children":"NIH program"}]," (",2024,")","$undefined"]}]}] 17:["$","script","script-0",{"src":"/_next/static/chunks/1d1y7uymgsv0g.js","async":true,"nonce":"$undefined"}] 18:["$","$L1f",null,{"children":["$","$1d",null,{"name":"Next.MetadataOutlet","children":"$@20"}]}] 1b:[["$","meta","0",{"charSet":"utf-8"}],["$","meta","1",{"name":"viewport","content":"width=device-width, initial-scale=1"}]] 21:I[27201,["/_next/static/chunks/29xvpf6gzvbvu.js","/_next/static/chunks/1-8s9_t85wwr4.js"],"IconMark"] 1e:[["$","title","0",{"children":"Spike Protein Therapeutics — Block, Degrade & Clear | spikeprotein.online"}],["$","meta","1",{"name":"description","content":"COVID-19 and Long COVID therapeutics claimed to block, degrade, or clear SARS-CoV-2 spike protein: mAbs, apheresis, nattokinase, autophagy inducers, with clinical support tiers."}],["$","meta","2",{"name":"keywords","content":"spike protein therapeutics,spike protein clearance,nattokinase spike,long COVID treatment spike,apheresis long COVID"}],["$","meta","3",{"property":"og:title","content":"spikeprotein.online"}],["$","meta","4",{"property":"og:description","content":"Scientific data on spike protein persistence, symptoms, mechanisms, and therapeutics."}],["$","meta","5",{"property":"og:url","content":"https://spikeprotein.online"}],["$","meta","6",{"property":"og:type","content":"website"}],["$","meta","7",{"name":"twitter:card","content":"summary"}],["$","meta","8",{"name":"twitter:title","content":"spikeprotein.online"}],["$","meta","9",{"name":"twitter:description","content":"Scientific data on spike protein persistence, symptoms, mechanisms, and therapeutics."}],["$","link","10",{"rel":"icon","href":"/favicon.ico?favicon.2vob68tjqpejf.ico","sizes":"256x256","type":"image/x-icon"}],["$","$L21","11",{}]] 20:null